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On-the-Day-of-FMRI-Experiment.md

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+<br>Background: Motor cortex stimulation (MCS) is a probably efficient treatment for chronic neuropathic pain. The neural mechanisms underlying the reduction of hyperalgesia and allodynia after MCS are usually not utterly understood. Objective: To analyze the neural mechanisms accountable for analgesic effects after MCS. We take a look at the speculation that MCS attenuates evoked blood oxygen-degree dependent alerts in cortical areas involved in nociceptive processing in an animal model of chronic neuropathic pain. 10) that obtained unilateral electrolytic lesions of the right spinal cord at the level of C6 (SCL animals). In these animals, we carried out magnetic resonance imaging (fMRI) experiments to check the analgesic effects of MCS. On the day of fMRI experiment, 14 days after spinal cord lesion, the animals had been anesthetized and epidural bipolar platinum electrodes were placed above the left main motor cortex. Two 10-min classes of fMRI were carried out before and after a session of MCS (50 μA, 50 Hz, 300 μs, for 30 min). During every fMRI session, the precise hindpaw was electrically stimulated (noxious stimulation: 5 mA, 5 Hz, 3 ms) utilizing a block design of 20 s stimulation off and 20 s stimulation on. A normal linear mannequin-based statistical parametric evaluation was used to investigate whole mind activation maps. Region of curiosity (ROI) evaluation and paired t-take a look at had been used to check changes in activation before and after MCS in these ROI.<br>
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